Insulin Sensitizers

Oral medications: IV Insulin Sensitizers

Insulin sensitizers include the drugs rosiglitazone (Avandia®) and pioglitazone (ActosTM). These drugs increase the sensitivity of tissues to insulin by stimulating a receptor in the body called the PPAR gamma receptor. Insulin effects the expression of many genes involved in the control of glucose production, transport, and use, and PPAR gamma receptors are involved in many of these actions. The major side effects include weight gain, mild swelling, headache and a slight decrease in blood hemoglobin levels. Blood tests to monitor the effects of the drug on the liver are often conducted, especially during initial therapy.